Afzal N, et al. Constipation with acquired megarectum in children with autism. Pediatrics. 2003 Oct;112(4):939-42.
Arvilommi H, Isolauri E.Kalliomäki M, Poussa T, Salminen S. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet. 2003 361(9372):1869-71.
Ashwood P et al. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. J Clin Immunol. 2003 Nov;23(6):504-17.
Ashwood P, Wakefield AJ. Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. J Neuroimmunol. 2006 Apr;173(1-2):126-34.
Balzola F, Barbon V, Repici A, Rizzetto M. Panenteric IBD-like disease in a patient with regressive autism shown for the first time by the wireless capsule enteroscopy: another piece in the jigsaw of this gut-brain syndrome? Am J Gastro. 2005; 979-981.
Balzola F, et al. Autistic enterocolitis: confirmation of a new inflammatory bowel disease in an Italian cohort of patients. Gastroenterology. 2005;128:Suppl.2;A-303.
Balzola F, et al. Autistic Enterocolitis in childhood: the early evidence of the later Crohn’s disease in autistic adulthood? Gastroenterology April 2007 Vol 132, N. 4, suppl 2 W 1100 A 660
Balzola F, et al. Beneficial behavioural effects of IBD therapy and gluten/casein-free diet in an Italian cohort of patients with autistic enterocolitis followed over one year. Gastroenterology, April 2006 Vol 130 Number 4 suppl. 2 S1364 A-21.
Biller JA, Katz AJ, Flores AF, Buie TM, Gorbach SL. Treatment of recurrent Clostridium difficile colitis with Lactobacillus GG. J Pediatr Gastroenterol Nutr. 1995 Aug;21(2):224-6.
Billoo AG, Memon MA, Khaskheli SA, et al. Role of probiotic Saccharomyces boulardii in management and prevention of diarrhea. World J Gastroenterol. 2006;12:4557-4560.
Black C, Kaye JA, Jick H. Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database. BMJ. 2002 Aug 24;325(7361):419-21.
Binstock T. Intra-monocyte pathogens delineate autism subgroups. Med Hypotheses. 2001 Apr;56(4):523-31.
Binstock T. Anterior insular cortex: linking intestinal pathology and brain function in autism-spectrum subgroups. Med Hypotheses 2001 57(6):714-7.
Borruel N, et al. Increased mucosal tumour necrosis factor alpha production in Crohn’s disease can be downregulated ex vivo by probiotic bacteria. Gut. 2002 Nov;51(5):659-64.
Bousvaros A,et al; and the Members of the Challenges in Pediatric IBD Study Groups. Challenges in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2006 Sep;12(9):885-913.
Buchman AL, et al. Hyperbaric oxygen therapy for severe ulcerative colitis. J Clin Gastroenterol. 2001Oct;33(4):337-9.
Buts JP, De Keyser N. Effects of Saccharomyces boulardii on intestinal mucosa. Dig Dis Sci. 2006 Aug;51(8):1485-92.
Cade R, et al. Autism and schizophrenia: intestinal disorders. Nutritional Neuroscience 3: 57-72, 2000.
Cade JR, et al. Autism and schizophrenia linked to malfunctioning enzyme for milk protein digestion. Autism, Mar 1999.
Czerucka D, et al. Experimental effects of Saccharomyces boulardii on diarrheal pathogens. Microbes Infect, 2002. 4(7): p. 733-9.
DeFelice ML, et al. Intestinal cytokines in children with pervasive developmental disorders. Am J Gastroenterol 98(8): 1777-82: 2003.
del Giudice MM, Brunese FP. Probiotics, prebiotics, and allergy in children: what’s new in the last year? J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 2:S205-8.
D’Eufemia P, et al. Abnormal intestinal permeability in children with autism. Acta Paediatr. 1996 Sep;85(9):1076-9.
Fedorak RN, Madsen KL. Probiotics and the management of inflammatory bowel disease. Inflamm Bowel Dis. 2004 May;10(3):286.
Forsberg G, et al. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am J Gastroenterol. 2004 May;99(5):894-904.
Furlano RI, et al. Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. J Pediatr. 2001 Mar;138(3):366-72.
Ghosh S, et al. Probiotics in inflammatory bowel disease: is it all gut flora modulation? Gut. 2004 May;53(5):620-2.
Gonzalez L, Lopez K, Navarro D, Negron L, Flores L, Rodriguez R, Martinez M, Sabra A. Endoscopic and Histological Characteristics of the digestive mucosa in autistic children with gastrointestinal symptoms. Arch Venez Pueric Pediatr 69;1:19-25
Gottschall, Elaine G. Breaking the Vicious Cycle: Intestinal Health Through Diet. Ontario: Kirkton Press. 1994.
Hadjivassiliou M et al. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.
Hart AL, et al. Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut. 2004 Nov;53(11):1602-9.
Haskey N, Dahl WJ. Synbiotic therapy: a promising new adjunctive therapy for ulcerative colitis. Nutr Rev. 2006 Mar;64(3):132-8.
Hassall E. Decisions in diagnosing and managing chronic gastroesophageal reflux disease in children. J Pediatr. 2005 Mar;146(3 Suppl):S3-12.
Homan M, Baldassano RN, Mamula P. Managing complicated Crohn’s disease in children and adolescents. Nat Clin Pract Gastroenterol Hepatol. 2005 Dec;2(12):572-9.
Horvath K et al. Gastrointestinal abnormalities in children with autistic disorder. J Pediatr. 1999 Nov;135(5):559-63.
Horvath K, Perman JA. Autism and gastrointestinal symptoms. Curr Gastroenterol Rep. 2002 Jun;4(3):251-8.
Horvath K, Perman JA. Autistic disorder and gastrointestinal disease. Curr Opin Pediatr. 2002 Oct;14(5):583-7.
Iacono G et al. Intolerance of cow’s milk and chronic constipation in children. N Engl J Med. 1998 Oct 15;339(16):1100-4.
Işeri SO, Sener G, Sağlam B, Gedik N, Ercan F, Yeğen BC. Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism. Peptides. 2005 Mar;26(3):483-91.
Kawashima H et al. Detection and sequencing of measles virus from peripheral mononuclear cells from patients with inflammatory bowel disease and autism. Dig Dis Sci. 2000 Apr;45(4):723-9.
Koch TR, et al. Induction of enlarged intestinal lymphoid aggregates during acute glutathione depletion in a murine model. Dig Dis Sci 2000. 45(11): 2115-21.
Kruis W. Antibiotics and probiotics in inflammatory bowel disease. Aliment Pharmacol Ther. 2004 Oct;20 Suppl 4:75-8.
Kuddo T, Nelson KB. How common are gastrointestinal disorders in children with autism. Curr Opin Pediatr 2003: 15(3); 339-343.
Kushak R, Winter H, Farber N, Buie T. Gastrointestinal symptoms and intestinal disaccharidase activities in children with autism. Abstract of presentation to the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition, Annual Meeting, October 20-22, 2005, Salt Lake City, Utah.
Levy S, et al. Children with autistic spectrum disorders. I: Comparison of placebo and single dose of human synthetic secretin. Arch. Dis. Child. 2003;88;731-736.
Lewis JD, et al. An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis. Am J Gastroenterol. 2001 Dec;96(12):3323-8.
Liu Z, Li N, Neu J. Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatr. 2005 Apr;94(4):386-93.
Macdonald A. Omega-3 fatty acids as adjunctive therapy in Crohn’s disease. Gastroenterol Nurs. 2006 Jul-Aug;29(4):295-301.
Melmed RD, Schneider CK, Fabes RA. Metabolic markers and gastrointestinal symptoms in children with autism and related disorders. J Pediatr Gastroenterol Nutr 2000:31(suppl 2)S31-32.
Ménard S, Candalh C, Bambou JC, Terpend K, Cerf-Bensussan N, Heyman M. Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport. Gut. 2004 Jun;53(6):821-8.
Parracho HM, Bingham MO, Gibson GR, McCartney AL. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol. 2005 Oct;54(Pt 10):987-91.
Qin HL, Shen TY, Gao ZG, Fan XB, Hang XM, Jiang YQ, Zhang HZ. Effect of lactobacillus on the gut microflora and barrier function of rats with abdominal infection. World J Gastroenterol. 2005 May 7;11(17):2591-6.
Quigley EM, Hurley D. Autism and the gastrointestinal tract. Am J Gastroenterol. 2000 Sep;95(9):2154-6.
Reichelt KL, Knivsberg AM. Can the pathophysiology of autism be explained by the nature of the discovered urine peptides? Nutr Neurosci. 2003 Feb;6(1):19-28.
Reichelt KL, et al. Probable Etiology and Possible Treatment of Childhood Autism. Brain Dysfuntion 1991; 4: 308-319.
Rimland, B. Secretin treatment for autism. N Engl J Med 2000. 342(16): 1216-7; author reply 1218.
Romano C, et al. Usefulness of omega-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn’s disease: a double-blind, randomized, placebo-controlled study. World J Gastroenterol. 2005 Dec 7;11(45):7118-21.
Salminen S, Isolauri E, Salminen E. Clinical uses of probiotics for stabilizing the gut mucosal barrier: successful strains and future challenges. Antonie Van Leeuwenhoek. 1996 Oct;70(2-4):347-58.
Sandler RH, et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol. 2000 Jul;15(7):429.
Schneider CK, Melmed RD, Barstow LE, Enriquez FJ, Ranger-Moore J, Ostrem JA. Oral Human Immunoglobulin for Children with Autism and Gastrointestinal Dysfunction: A Prospective, Open-Label Study. J Autism Dev Disord. 2006 Jul 15.
Sido B, Hack V, Hochlehnert A, Lipps H, Herfarth C, Droge W. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut. 1998 Apr;42(4):485-92.
Sienkiewicz-Szapka E, et al. Transport of bovine milk derived opioid peptides across a Caco-2 monolayer, Int Dairy J. 2008.
Song Y, Liu C, Finegold SM. Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol. 2004 Nov;70(11):6459-65.
Sougioultzis S, et al. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun. 2006 Apr 28;343(1):69-76.
Sturniolo, G.C., et al. Zinc supplementation tightens “leaky gut” in Crohn’s disease. Inflamm Bowel Dis, 2001. 7(2): p. 94-8.
Surawicz CM. Probiotics, antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in humans. Best Pract Res Clin Gastroenterol. 2003 Oct;17(5):775-83.
Taylor B, Miller E, Lingam R, Andrews N, Simmons A, Stowe J. Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ. 2002 Feb 16;324(7334):393-6.
Torrente F, Anthony A. Focal-enhanced gastritis in regressive autism with features distinct from Crohn’s disease and helicobacter Pylori gastritis. Am J Gastroenterol 2004 Apr;99(4):598-605.
Torrente F et al. Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Mol Psychiatry. 2002;7(4):375-82, 334.
Uhlmann V et al. Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Mol Pathol. 2002 Apr;55(2):84-90.
Valicenti-McDermott M, et al. Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S128-36.
Valicenti-McDermott MD, McVicar K, Cohen HJ, Wershil BK, Shinnar S. Gastrointestinal symptoms in children with an autism spectrum disorder and language regression. Pediatr Neurol. 2008 Dec;39(6):392-8.
Wakefield AJ, Ashwood P, Limb K, Anthony A. The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. Eur J Gastroenterol Hepatol. 2005 Aug;17(8):827-36.
Wakefield AJ et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. 1998 28;351(9103):637-41.
Wakefield AJ. Enterocolitis, autism and measles virus. Mol Psychiatry. 2002;7 Suppl 2:S44-6.
Wakefield AJ. The gut-brain axis in childhood developmental disorders. J Pediatr Gastroenterol Nutr. 2002 May-Jun;34 Suppl 1:S14-7.
Wakefield AJ et al. Review article: the concept of entero-colonic encephalopathy, autism and opioid receptor ligands. Aliment Pharmacol Ther 2002 16(4):663-74.
Wakefield AJ et al. Enterocolitis in children with developmental disorders. Am J Gastroenterol. 2000 Sep;95(9):2285-95.
Wakefield AJ, et al. Autism, viral infection and measles-mumps-rubella vaccination. Isr Med Assoc J. 1999 Nov;1(3):183-7.
Wakefield AJ. MMR vaccination and autism. Lancet. 1999 Sep 11;354(9182):949-50.
Welch MG, Welch-Horan TB, Anwar M, Anwar N, Ludwig RJ, Ruggiero DA. Brain effects of chronic IBD in areas abnormal in autism and treatment by single neuropeptides secretin and oxytocin. J Mol Neurosci 2005; 25(3):259-74.
White JF. Intestinal pathophysiology in autism. Exp Biol Med (Maywood). 2003 Jun;228(6):639-49.
Whiteley P, Shattock P. Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention. Expert Opin Ther Targets. 2002 Apr;6(2):175-83.
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Goin-Kochel RP, Mackintosh VH, Myers, BJ. Parental reports on the efficacy of treatments and therapies of their children with autism spectrum disorders. Res Autism Spectr Disord. 2009, doi:10.1016/j.rasd.2008.11.001.
O’Hara NH, Szakacs GM. The recovery of a child with autism spectrum disorder through biomedical interventions. Altern Ther Health Med. 2008 Nov-Dec;14(6):42-4.
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Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water J. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disord. 2008 Jan;38(1):169-75.
Ashwood P, et al. Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10. J Clin Immunol. 2004 Nov;24(6):664-73.
Ashwood P, Van de Water J. Is autism an autoimmune disease? Autoimmun Rev. 2004 Nov;3(7-8):557-62.
Ashwood P, et al. The immune response in autism: a new frontier for autism research. J Leuk Biol. 2006 Jul:80;1-15.
Bayary J, et al. Intravenous immunoglobulin in autoimmune disorders: an insight into the immunoregulatory mechanisms. Int Immunopharmacol. 2006 Apr;6(4):528-34.
Boris M, et al. Improvement in children treated with intravenous gamma globulin. J Nutr Environmental Med. Dec 2006; 15(4):1-8.
Boris M, et al. Effect of Pioglitazone treatment on behavioral symptoms in autistic children. J Neuroinflammation. 2007 Jan 5;4:3.
Bradstreet JJ, Smith S, Granpeesheh D, El-Dahr JM, Rossignol D. Spironolactone Might be a Desirable Immunologic and Hormonal Intervention in Autism Spectrum Disorders. Med Hypotheses. 2006 Dec 4.
Brandtzaeg P. Current Understanding of Gastrointestinal Immunoregulation and Its Relation to Food Allergy. Ann NY Acad Sci. 2002;964:14-45.
Braunschweig D, et al. Autism: Maternally derived antibodies specific for fetal brain proteins. Neurotoxicology. 2007 Nov 6.
Bray TM, Taylor CG. Enhancement of tissue glutathione for antioxidant and immune functions in malnutrition. Biochem Pharmacol. 1994 Jun 15;47(12):2113-23.
Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann N Y Acad Sci. 2007 Jun;1107:92-103.
Cave SF. The history of vaccinations in the light of the autism epidemic. Altern Ther Health Med. 2008 Nov-Dec;14(6):54-7.
Chinetti G, Fruchart JC, Staels B. Peroxisome proliferators-activated receptors (PPAR): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 2000;49:497-505.
Cohly HH, Panja A. Immunological findings in autism. Int Rev Neurobiol. 2005;71:317-41.
Chmelik, E., N. Awadallah, et al. (2004). Varied presentation of PANDAS: a case series. Clin Pediatr (Phila) 43(4): 379-82.
Connolly AM, Chez MG, Pestronk A, Arnold ST, Mehta S, Deuel RK. Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. J Pediatr. 1999 May;134(5):607-13.
Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J. Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. Arch Pediatr Adolesc Med. 2005 Feb;159(2):151-7.
Croonenberghs J, Wauters A, Devreese K, Verkerk R, Scharpe S, Bosmans E, Egyed B, Deboutte D, Maes M. Increased serum albumin, gamma globulin, immunoglobulin IgG, and IgG2 and IgG4 in autism. Psychol Med. 2002 Nov;32(8):1457-63.
Croonenberghs J, et al. Activation of the inflammatory response system in autism. Neuropsychobiology 2002, 45(1):1-6.
Cross ML. Immune-signalling by orally-delivered probiotic bacteria: effects on common mucosal immunoresponses and protection at distal mucosal sites. Int J Immunopathol Pharmacol. 2004 May-Aug;17(2):127-34.
Dalton P, et al. Maternal neuronal antibodies associated with autism and a language disorder. Ann Neurol. 2003 Apr;53(4):533-7.
DelGiudice-Asch G, Simon L, Schmeidler J, Cunningham-Rundles C, Hollander E. Brief report: A pilot open clinical trial of intravenous immunoglobulin in childhood autism. J Autism Dev Disord. 1999:29(2):157-60..
Denney DR, et al. Lymphocyte subsets and interleukin-2 receptors in autistic children. J Autism Dev Disord. 1996 Feb;26(1):87-97.
Dietert RR, Dietert JM. Potential for early-life immune insult including developmental immunotoxicity in autism and autism spectrum disorders: focus on critical windows of immune vulnerability.J Toxicol Environ Health B Crit Rev. 2008 Oct;11(8):660-80.
Drakes M, Blanchard T, Czinn S. Bacterial probiotic modulation of dendritic cells. Infect Immun. 2004 Jun;72(6):3299-309.
Droge W, Breitkreutz R. Glutathione and immune function. Proc Nutr Soc. 2000 Nov;59(4):595-600.
Elchaar GM, Maisch NM, Augusto LM, Wehring HJ. Efficacy and safety of naltrexone use in pediatric patients with autistic disorder. Ann Pharmacother. 2006 Jun;40(6):1086-95.
Engstrom HA, Ohlson S, Stubbs EG, Maciulis A, Caldwell V, Odell JD, Torres A.R. Decreased Expression of CD95 (FAS/APO-1) on CD4+ T-lymphocytes from Participants with Autism. J Dev Phys Disabil. 2003 Jun 15;2:155-163(9).
Ferrante P, Saresella M, Guerini FR, Marzorati M, Musetti MC, Cazzullo AG. Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children. Biomed Pharmacother. 2003 Oct;57(8):372-4.
Feinstein DL. Therapeutic potential of peroxisome proliferator-activated receptor agonists for neurological disease. Diabetes Technol Ther. 2003;5(1):67-73.
Fudenberg HH. Dialysable lymphocyte extract (DLyE) in infantile onset autism: a pilot study. Biotherapy. 1996;9(1-3):143-7.
Furlano RI, et al. Autism and the immune system. J Child Psychol Psychiatry. 1997 Mar;38(3):337-49.Griem P., et al.; Allergic and autoimmune reactions to xenobiotics: how do they arise? Immunology Today 19: 133-141, 1998.
Gao HM, Hong JS. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol. 2008 Aug;29(8):357-65.
Geier DA, Geier MR. A Clinical and Laboratory Evaluation of Methionine Cycle-Transsulfuration and Androgen Pathway Markers in Children with Autistic Disorders. Horm Res. 2006 Jul 5;66(4):182-188.
Geier DA, Mumper E, Gladfelter B, Coleman L, Geier MR. Neurodevelopmental disorders, maternal Rh-negativity, and Rho(D) immune globulins: a multi-center assessment. Neuro Endocrinol Lett. 2008 Apr;29(2):272-80.
Griem P, et al. Allergic and autoimmune reactions to xenobiotics: how do they arise? Immunology Today 19: 133-141, 1998.
Gupta S. Immunological treatments for autism. J Autism Dev Disord. 2000 Oct;30(5):475-9.
Gupta S, Aggarwal S, Heads C. Dysregulated immune system in children with autism: beneficial effects of intravenous immune globulin on autistic characteristics. J Autism Dev Disord. 1996 Aug;26(4):439-52.
Gupta S, et al. Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol. 1998 May 1;85(1):106-9.
Hamilton, RG, et al. In vitro assays for the diagnosis of IgE-mediated disorders. J Allergy Clin Immunol 114(2): 213-25.
Hertz-Picciotto I, Park HY, Dostal M, Kocan A, Trnovec T, Sram R. Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development. Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):146-54.
Jyonouchi H, et al. Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. J Pediatr. 2005 May;146(5): 605-10.
Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H. Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study. J Neuroinflammation. 2008 Nov 21;5(1):52.
Jyonouchi H, Sun S, Le H. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune re-sponses in children with autism spectrum disorders and developmental regression. J Neuroimmunol. 2001 Nov 1;120(1-2):170-9.
Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology. 2002;46(2):76-84.
Jyonouchi H, Geng L, Ruby A, Zimmerman-Bier B. Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention. Neuropsychobiology. 2005;51(2):77-85.
Kelly GS. Bovine colostrums: a review of clinical uses. Altern Med Rev. 2003 Nov;8(4):378-94.
Kidd PM. Autism, an extreme challenge to integrative medicine. Part 2: medical management. Altern Med Rev. 2002 Dec;7(6):472-.
Kirjavainen PV, et al. New aspects of probiotics–a novel approach in the management of food allergy. Allergy. 1999 Sep;54(9):909.
Knickmeyer R, Baron-Cohen S, Raggatt P, Taylor K. Foetal testosterone, social relationships, and restricted interests in children. J Child Psychol Psychiatry. 2005 Feb;46(2):198-210.
Konstantareas MM, Homatidis S. Ear infections in autistic and normal children. J Autism Dev Disord. 1987 Dec;17(4):585-94.
Koski CL, Patterson JV. Intravenous immunoglobulin use for neurologic diseases. J Infus Nurs. 2006 May-Jun;29(3 Suppl):S21-8.
Krause I, et al. Brief report: immune factors in autism: a critical review. J Autism Dev Disord. 2002 Aug;32(4):337-45.
Li X, et al. Elevated immune response in the brain of autistic patients. J Neuroimmunol. 2009 Jan 19.
Lipkin WI, Hornig M. Microbiology and immunology of autism spectrum disorders. Novartis Found Symp. 2003;251:129-43; discussion 144-8, 281-97.
Lucarelli S et al. Food allergy and infantile autism. Panminerva Med. 1995 Sep;37(3):137-41.
March JS. Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection (PANDAS): implications for clinical practice. Arch Pediatr Adolesc Med 2004, 158(9): 927-9.
Martin LA, Ashwood P, Braunschweig D, Cabanlit M, Van de Water J, Amaral DG. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav Immun. 2008 Feb 7.
Messahel S, et al. Urinary levels of neopterin and biopterin in autism. Neurosci Lett 1998, 241(1): 17-20.
McDonald KL, Huq SI, Lix LM, Becker AB, Kozyrskyj AL. Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma. J Allergy Clin Immunol. 2008
Meffert M, Baltimore D. Physiological Functions of brain NF-KB. Trends in Neurosciences. 2005;28(1):37-43.
Meyer U, Nyffeler M, Engler A, Urwyler A, Schedlowski M, Knuesel I, Yee BK, Feldon J. The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci. 2006 May 3;26(18):4752-62.
Molloy C, et al. Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunology. 2006;172:198-205.
Mouridsen SE, Rich B, Isager T, Nedergaard NJ. Autoimmune diseases in parents of children with infantile autism: a case-control study. Dev Med Child Neurol. 2008 Jun;49(6):429-32.
Niehus R, Lord C. Early medical history of children with autism spectrum disorders. J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S120-7.
Okada K, et al. Decreased serum levels of transforming growth factor-beta1 in patients with autism. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Oct 5.
Pardo CA, et al. Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry. 2005 Dec;17(6):485-95.
Patterson PH. Immune involvement in schizophrenia and autism: Etiology, pathology and animal models.Behav Brain Res.2008 Dec.
Pessah IN, et al. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology. 2008.
Plioplys AV. Intravenous immunoglobulin treatment of children with autism. J Child Neurol. 1998 Feb;13(2):79-82.
Rampersad GC, et al. Chemical compounds that target thiol-disulfide groups on mononuclear phagocytes inhibit immune mediated phagocytosis of red blood cells. Transfusion 2005, 45(3): 384-93.
Reichenberg A, et al. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 2001, 58(5): 445.
Schneider CK, Melmed RD, Barstow LE, Enriquez FJ, Ranger-Moore J, Ostrem JA. Oral Human Immunoglobulin for Children with Autism and Gastrointestinal Dysfunction: A Prospective, Open-Label Study. J Autism Dev Disord. 2006 Jul 15.
Scifo R, et al. Opioid-immune interactions in autism: behavioural and immunological assessment during a double-blind treatment with naltrexone. Ann Ist Super Sanita. 1996;32(3):351-9.
Silva SC, et al. Autoantibody repertoires to brain tissue in autism nuclear families. J Neuroimmunol. 2004 Jul;152(1-2):176-82.
Singer HS, et al. Antibrain antibodies in children with autism and their unaffected siblings. J Neuroimmunol. 2006 Sep;178(1-2):149.
Singer HS, et al. Antibodies against fetal brain in sera of mothers with autistic children. J Neuroimmunol. 2008 Feb;194(1-2):165-72.
Singh VK. Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism. J Neuroimmunol. 1996 May;66(1-2):143-5.
Singh VK. Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol. 1998 May 1;85(1):106-9.
Singh VK, et al. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr Neurol. 1997 Jul;17(1):88-90.
Singh VK, et al. Antibodies to myelin basic protein in children with autistic behavior. Brain Behav Immun. 1993 Mar;7(1):97-103.
Singh VK, Singh EA, Warren RP. Hyperserotoninemia and serotonin receptor antibodies in children with autism but not mental retardation. Biol Psychiatry. 1997 Mar 15;41(6):753-5.
Singh VK, Rivas WH. Prevalence of serum antibodies to caudate nucleus in autistic children. Neurosci Lett. 2004 Jan 23;355(1-2):53-6.
Siragam V, Crow AR, Brinc D, Song S, Freedman J, Lazarus AH. Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells. Nat Med. 2006 Jun;12(6):688-92.
Stubbs EG, et al. Depressed lymphocyte responsiveness in autistic children. J Autism Child Schizophr. 1977 Mar;7(1):49-55.
Stubbs EG, Budden SS, Burger DR, Vandenbark AA. Transfer factor immunotherapy of an autistic child with congenital cytomegalovirus. J Autism Dev Disord. 1980 Dec;10(4):451-8.
Suh JH, Walsh WJ, McGinnis WR, Lewis A, Ames BN. Altered Sulfur Amino Acid Metabolism In Immune Cells of Children Diagnosed With Autism. Am J Biochem Biotechnol 4(2): 105-113, 2008.
Swedo SE, et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998 Feb;155(2):264-71.
Swedo SE, Leonard HL, Rapoport JL. The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction. Pediatrics. 2004 Apr;113(4):907-11.
Swedo SE, Grant PJ. Annotation: PANDAS: a model for human autoimmune disease. J Child Psychol Psychiatry. 2005 Mar;46(3):227-34.
Sweeten TL, et al. Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics. 2003.
Sweeten TL, Posey DJ, McDougle CJ. High blood monocyte counts and neopterin levels in children with autistic disorder. Am J Psychiatry. 2003 Sep;160(9):1691-3.
Sweeten TL, Posey DJ, Shankar S, McDougle CJ. High nitric oxide production in autistic disorder: a possible role for interferon-gamma. Bio Psychiatry. 2004 Feb 15:55(4):434-7.
Todd RD, Hickok JM, Anderson GM, Cohen DJ. Antibrain antibodies in infantile autism. Biol Psychiatry. 1988 Mar 15;23(6):644-7.
Trajkovski V, Ajdinski L, Spiroski M. Plasma concentration of immunoglobulin classes and subclasses in children with autism in the Republic of Macedonia: retrospective study. Croat Med J. 2004 Dec;45(6):746-9.
Vojdani A, et al. Low natural killer cell cytotoxic activity in autism: The role of glutathione, IL-2 and IL-15. J Neuroimmunol. 2008 Dec 15;205(1-2):148-54.
Vojdani A, et al. Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. J Neuroimmunol. 2002 Aug;129(1-2):168-77.
Vojdani A, et al. Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. International J Immunopathol Pharmacology 16: 189-199, 2003.
Vojdani A, O’Bryan T, Green JA, Mccandless J, Woeller KN, Vojdani E, Nourian AA, Cooper EL. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci. 2004 Jun;7(3):151-61.
Todd RD, Hickok JM, Anderson GM, Cohen DJ. Antibrain antibodies in infantile autism. Biol Psychiatry. 1988 Mar 15;23(6):644-7.
Trajkovski V, Ajdinski L, Spiroski M. Plasma concentration of immunoglobulin classes and subclasses in children with autism in the Republic of Macedonia: retrospective study. Croat Med J. 2004 Dec;45(6):746-9.
Vojdani A, et al. Low natural killer cell cytotoxic activity in autism: The role of glutathione, IL-2 and IL-15. J Neuroimmunol. 2008 Dec 15;205(1-2):148-54.
Vojdani A, et al. Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. J Neuroimmunol. 2002 Aug;129(1-2):168-77.
Vojdani A, et al. Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. International J Immunopathol Pharmacology 16: 189-199, 2003.
Vojdani A, O’Bryan T, Green JA, Mccandless J, Woeller KN, Vojdani E, Nourian AA, Cooper EL. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci. 2004 Jun;7(3):151-61.
Vojdani A, et al. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Clin Diagn Lab Immunol. 2004 May;11(3):515-24.
Wakefield AJ, Walker-Smith JA, Murch SH. Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. Pediatrics 2001;138:366-72.
Warren RP, et al. Immune abnormalities in patients with autism. J Autism Dev Disord. 1986 Jun;16(2):189.
Warren RP, et al. Detection of maternal antibodies in infantile autism. J Am Acad Child Adolesc Psychiatry. 1990 Nov;29(6):873-7.
Warren RP, et al. Reduced natural killer cell activity in autism. J Am Acad Child Adolesc Psychiatry. 1987 May;26(3):333-5.
Warren RP, et al. Immunogenetic studies in autism and related disorders. Mol Chem Neuropathol. 1996 May-Aug;28(1-3):77-81.
Wills S, et al. Autoantibodies in autism spectrum disorders (ASD). Ann N Y Acad Sci. 2007 Jun;1107:79-91.
Yonk LJ, et al. CD4+ helper T cell depression in autism. Immunol Lett. 1990 Sep;25(4):341-5.
Youseff S, Steinman L. At once harmful and beneficial: the dual properties of NFKB. Nature Immunology. 2006; 7(9):901-902
Zimecki M, Artym J. Therapeutic properties of proteins and peptides from colostrum and milk. Postepy Hig Med Dosw. 2005;59:309-23.
Zimmerman AW, et al. Maternal antibrain antibodies in autism. Brain Behav Immun. 2006 Oct 5.
Zimmerman AW, et al. Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol. 2005 Sep;33(3):195.
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[accordion_toggle title=”Nutritional Deficiencies, Supplements and Diets Research”]
Adams JB, Holloway C. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. J Altern Complement Med. 2004 Dec;10(6):1033-9.
Adams JB, George F, Audhya T. Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006 Jan-Feb;12(1):59-63.
Aldred S, et al. Plasma amino acid levels in children with autism and their families. J Autism Dev Disord. 2003 Feb;33(1):93-7.
Amminger GP, Berger GE, Schafer MR, Klier C, Friedrich MH, Feucht M. Omega-3 Fatty Acids Supplementation in Children with Autism: A Double-blind Randomized, Placebo-controlled Pilot Study. Biol Psychiatry. 2006 Aug 22.
Andersen IM, et al. Melatonin for Insomnia in Children With Autism Spectrum Disorders. J Child Neurol. 2008 Jan 8.
Arnold GL et al. Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies. J Autism Dev Disord 2003 33(4):449-54.
Ashkenazi A, Levin S, Krasilowsky D. Gluten and autism. Lancet. 1980 Jan 19;1(8160):157.
Baker SB, Worthley LI. The essentials of calcium, magnesium and phosphate metabolism: part I. Physiology. Crit Care Resusc. 2002 Dec;4(4):301-6.
Barthelemy C, et al. Biological and clinical effects of oral magnesium and associated magnesium-vitamin B6 administration on certain disorders observed in infantile autism. Therapie. 1980 Sep-Oct;35(5):627-32.
Bolman WM, Richmond JA. A double-blind, placebo-controlled, crossover pilot trial of low dose dimethylglycine in patients with autistic disorder. J Autism Dev Disord. 1999 Jun;29(3):191-4.
Bruni O, et al. L -5-Hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr. 2004 Jul;163(7):402-7.
Bubenik GA, et al. Propsects of the clinical utilization of melatonin. Biological Signals and Receptors. 1998;7:195-219.
Bu B, Ashwood P, Harvey D, King IB, Water JV, Jin LW. Fatty acid compositions of red blood cell phospholipids in children with autism. Prostaglandins Leukot Essent Fatty Acids. 2006 Apr;74(4):215-21.
Carlton R et al. Rational dosages of nutrients have a prolonged effect on learning disabilities. Alternative Therapies 2000; 6:85-91.
Christison GW, Ivany K. Elimination diets in autism spectrum disorders: any wheat amidst the chaff? J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S162-71.
Connors SL, Crowell DE. Secretin and autism: the role of cysteine. J Am Acad Child Adolesc Psychiatry. 1999 Jul;38(7):795-6.
Curtis LT, Patel K. Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder (ADHD): a review. J Altern Complement Med. 2008 Jan-Feb;14(1):79-85.
Dolske MC, Spollen J, McKay S, Lancashire E, Tolbert L. A preliminary trial of ascorbic acid as supplemental therapy for autism. Prog Neuropsychopharmacol Biol Psychiatry. 1993 Sep;17(5):765-74.
Elder JH. The gluten-free, casein-free diet in autism: an overview with clinical implications. Nutr Clin Pract. 2008 Dec-2009 Jan;23(6):583-8.
El Idrissi A et al. Prevention of epileptic seizures by taurine. Adv Exp Med Biol. 2003;526:515-25.
Erdeve O et al. The probiotic effect of Saccharomyces boulardii in a pediatric age group. J Trop Pediatr. 2004 Aug;50(4):234-6.
Fernstrom JD. Can nutrient supplements modify brain function? Am J Clin Nutr. 2000 Jun;71(6 Suppl):1669S-75S.
Finegold SM et al. Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis 2002 35 (Suppl 1):S6-S16.
Giannotti F, Cortesi F, Cerquiglini A, Bernabei P. An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism. J Autism Dev Disord. 2006 Aug;36(6):741-52.
Gill HS, Rutherfurd KJ, Prasad J, Gopal PK. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr. 2000 Feb;83(2):167-76.
Grattan-Smith PJ, Wilcken B, Procopis PG, Wise GA. The neurological syndrome of infantile cobalamin deficiency: developmental regression and involuntary movements. Mov Disord. 1997 Jan;12(1):39-46.
Herbert V. Detection of malabsorption of vitamin B12 due to gastric or intestinal dysfunction. Semin Nucl Med. 1972 Jul;2(3):220.
Ishizaki A, Sugama M, Takeuchi N. Usefulness of melatonin for developmental sleep and emotional/behavior disorders—studies of melatonin trial on 50 patients with developmental disorders. No To Hattatsu. 1999 Sep;31(5):428-37.
Jonas C, Etienne T, Barthelemy C, Jouve J, Mariotte N. Clinical and biochemical value of Magnesium + vitamin B6 combination in the treatment of residual autism in adults. Therapie. 1984 Nov-Dec;39(6):661-9.
Jory J, McGinnis WR. Red-Cell Trace Minerals in Children with Autism. Am J Biochem Biotechnol. 4(2): 101-104, 2008.
Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M. Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder. J Child Neurol. 2001 Mar;16(3):169-73.
Kleijnen J, Knipschild P. Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans. Biol Psychiatry. 1991 May 1;29(9):931-41.
Knivsberg AM, et al. A randomised, controlled study of dietary intervention in autistic syndromes. Nutr Neurosci. 2002 Sep;5(4): 251-61.
Knivsberg AM, et al. Reports on dietary intervention in autistic disorders. Nutr Neurosci. 2001;4(1):25-37.
Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD). Magnes Res. 1997 Jun;10(2):143-8.
Lelord G, Muh JP, Barthelemy C, Martineau J, Garreau B, Callaway E. Effects of pyridoxine and magnesium on autistic symptoms—initial observations. J Autism Dev Disord. 1981 Jun;11(2):219-30.
Lelord G, Callaway E, Muh JP. Clinical and biological effects of high doses of vitamin B6 and magnesium on autistic children. Acta Vitaminol Enzymol. 1982;4(1-2):27-44.
Liebscher DH, Liebscher DE. About the misdiagnosis of magnesium deficiency. J Am Coll Nutr. 2004
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[accordion_toggle title=”Autism and Detoxification Research”]
Adams JB, Romdalvik J, Ramanujam V.M.S., Legator MS, Mercury, Lead, and Zinc in Baby Teeth of Children with Autism vs. Controls. J Toxicol Environ Health 2007 70(12):1046-51.
Adams JB, Romdalvik J, Levine KE, Hu LW. Mercury in first-cut baby hair of children with autism versus typically developing children. Toxic Environ Chem. 2008, 1-14, iFirst.
Alberti A, Pirrone P, Elia M, Waring RH, Romano C. Sulphation deficit in “low-functioning” autistic children: a pilot study. Biol Psychiatry. 1999 Aug 1;46(3):420-4.
Aposhian HV, Maiorino RM, Dart RC, Perry DF. Urinary excretion of meso-2,3-dimercaptosuccinic acid in human subjects. Clin Pharmacol Ther. 1989 May;45(5):520-6
Aremu DA, Madejczyk MS, Ballatori N. N-acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure. Environ Health Perspect. 2008 Jan;116(1):26-31.
Aschner M, Syversen T, Souza DO, Rocha JB. Metallothioneins: mercury species-specific induction and their potential role in attenuating neurotoxicity. Exp Biol Med (Maywood). 2006 Oct;231(9):1468-73.
Aw TY, Wierzbicka G, Jones DP. Oral glutathione increases tissue glutathione in vivo. Chem Biol Interact. 1991;80(1):89-97.
Aw TY. Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility. Toxicol Appl Pharmacol. 2005 May 1;204(3):320-8.
Bello SC. Autism and environmental influences: review and commentary. Rev Environ Health 2007: 22(2): 139-56.
Beversdorf DQ, Manning SE, et al. Timing of prenatal stressors and autism. J Autism Dev Disord 2005: 35(4): 471-8.
Blanusa M, et al. Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Curr Med Chem. 2005;12(23):2771.
Burbacher TM, Shen DD, Liberato N, Grant KS, Cernichiari E, Clarkson T. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ Health Perspect. 2005 Aug;113(8):1015-21.
Desoto MC, Hitlan RT. Blood Levels of Mercury Are Related to Diagnosis of Autism: A Reanalysis of an Important Data Set. J Child Neurol. 2007 Nov;22(11):1308-1311.
Dringen R, Hirrlinger J. Glutathione pathways in the brain. Biol Chem. 2003 384(4):505-16.
Edelson SB, Cantor DS. Autism: xenobiotic influences. Toxicol Ind Health. 1998 Jul-Aug;14(4):553-63.
Fonnum F, Lock EA. The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells. J Neurochem. 2004 Feb;88(3):513-31.
Forman J, et al. A cluster of pediatric metallic mercury exposure cases treated with meso-2,3-dimercaptosuccinic acid (DMSA). Environ Health Perspect. 2000 Jun;108(6):575-7.
Golse B, Debray-Ritzen P, Durosay P, Puget K, Michelson AM. Alterations in two enzymes: superoxide dismutase and glutathione peroxidase in developmental infantile psychosis (infantile autism). Rev Neurol (Paris). 1978 Nov;134(11):699-705.
Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN. Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal. Environ Health Perspect 2006; 114(7):1083-91.
Goyer RA, Cherian MG, Jones MM, Reigart JR. Role of chelating agents for prevention, intervention, and treatment of exposures to toxic metals. Environ Health Perspect. 1995 Nov;103(11):1048-52.
Grandjean P, Landrigan PJ. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78.
Graziano JH, Lolacono NJ, Moulton T, Mitchell ME, Slavkovich V, Zarate C. Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication. J Pediatr. 1992 Jan;120(1):133-9.
Havarinasab S, Hultman P. Organic mercury compounds and autoimmunity. Autoimmunity Rev 2005;4:270-275.
Havarinasab S, Haggqvist B, Bjorn E, Pollard KM, Hultman P. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol. 2005 Apr 15;204(2):109-21.
Hayes JD, et al. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology. 2000 Sep;61(3):154.
Holmes AS, et al. Reduced levels of mercury in first baby haircuts of autistic children. Int J Toxicol. 2003 Jul-Aug;22(4):277-85.
Hornig M, et al. Neurotoxic effects of postnatal thimerosal are mouse-strain dependent. Mol Psychiatry. 2004 Sep;9(9):833-45.
Hunjan MK, Evered DF. Absorption of glutathione from the gastro-intestinal tract. Biochim Biophys Acta. 1985 May 14;815(2):184.
Hurlbut KM, et al. Determination and metabolism of dithiol chelating agents. XVI: Pharmacokinetics of 2,3-dimercapto-1-propanesulfonate after intravenous administration to human volunteers. J Pharmacol Exp Ther. 1994 Feb;268(2):662-8.
Ip P, Wong V, Ho M, Lee J, Wong W. Mercury exposure in children with autistic spectrum disorder: case-control study. J Child Neurol. 2004 Jun;19(6):431-4.
Kern JK, Jones AM. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J Toxicol Environ Health B Crit Rev. 2006 Nov-Dec;9(6):485-99.
Kern JK, et al. Sulfhydryl-reactive metals in autism. J Toxicol Environ Health A. 2007 Apr 15;70(8):715-21.
Kinney DK, Miller AM, et al. Autism prevalence following prenatal exposure to hurricanes and tropical storms in Louisiana. J Autism Dev Disord 2008: 38(3): 481-8.
Lafleur DL, et al. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psycho-pharmacology (Berl). 2006 Jan;184(2):254-6.
Lanphear BP, et al. Low-level environmental lead exposure and children’s intellectual function: an international pooled analysis. Environ Health Perspect. 2005 Jul;113(7):894-9.
Lauterburg BH, Mitchell JR. Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man. J Hepatol. 1987 Apr;4(2):206-11.
Lonsdale D, Shamberger RJ, Audhya T. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuroendocrinol Lett. 2002 Aug;23(4):303-8.
Makani S, Gollapudi S, Yel L, Chiplunkar S, Gupta S. Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway. Genes Immun. 2002 Aug;3(5):270-8.
Mayer M, Noble M. N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7496-500.
Miller AL. Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity. Altern Med Rev. 1998 Jun;3(3):199-207.
Mutter J, Naumann J, et al. Mercury and autism: accelerating evidence? Neuro Endocrinol Lett 2005: 26(5): 439-46.
N-acetylcysteine [No authors listed]. Altern Med Rev. 2000 Oct;5(5):467-71.
Nataf R, Skorupka C, Amet L, Lam A, Springbett A, Lathe R. Porphyrinuria in childhood autistic disorder: implications for environ-mental toxicity. Toxicol Appl Pharmacol. 2006 Jul 15;214(2):99-108.
Oka S, Kamata H, Kamata K, Yagisawa H, Hirata H. N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases. FEBS Lett. 2000 Apr 28;472(2-3):196-202
Palmer RF, Blanchard S, Stein Z, Mandell D, Miller C. Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas. Health Place. 2006 Jun;12(2):203-9.
Palmer RF, Blanchard S, Wood R. Proximity to point sources of environmental mercury release as a predictor of autism prevalence. Health Place. 2008 Feb 12.
Pasca SP, Nemes B, Vlase L, Gagyi CE, Dronca E, Miu AC, Dronca M. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sci. 2006 Apr 4;78(19):2244-8.
Pastore A et al. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta. 2003 Jul 1;333(1):19-39.
Planas-Bohne F. The effect of 2,3-dimercaptorpropane-1-sulfonate and dimercaptosuccinic acid on the distribution and excretion of mercuric chloride in rats. Toxicology. 1981;19(3):275-8.
Rea WJ, Didriksen N, Simon TR, Pan Y, Fenyves EJ, Griffiths B. Effects of toxic exposure to molds and mycotoxins in building-related illnesses. Arch Environ Health. 2003 Jul;58(7):399-405.
Rose S, Melnyk S, et al. The frequency of polymorphisms affecting lead and mercury toxicity among children with autism. Am J Biochem Biotechnol 2008: 4(2): 85-94.
Shannon M, Graef JW. Lead intoxication in children with pervasive developmental disorders. J Toxicol Clin Toxicol. 1996;34(2):177-81.
Sheehan D et al. Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J. 2001 Nov 15;360(Pt 1):1-16.
Stangle DE, et al. Succimer chelation improves learning, attention and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure. Environ Health Perspect. 30 October 2006.
Testa B, et al. Management of chronic otitis media with effusion: the role of glutathione. Laryngoscope. 2001 Aug;111(8):1486-9.
Waly M, et al. Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Mol Psychiatry. 2004 Apr;9(4):358-7
Waring RH, Klovrza LV. Sulphur metabolism in autism. J Nutr Env Med. 2000;10:25-32.
Waring RH., et al. Biochemical parameters in autistic children. Dev Brain Dysfunction. 1997;10:40-43.
Westphal GA, et al. Homozygous gene deletions of the glutathione S-transferases M1 and T1 are associated with thimerosal sensiti-zation. Int Arch Occup Environ Health 2000 73(6):384-8.
Windham G, Zhang L, Gunier R, Croen L, Grether J. Autism Spectrum Disorders in Relation to Distribution of Hazardous Air Pollutants in the San Francisco Bay Area. Environ Health Perspect. 2006 Sep;114(9):1438-44.
Woods JS. Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity. Can J Physiol Pharmacol 1996. 74(2): 210-5.
Woods JS, et al. Studies on porphyrin metabolism in the kidney. Effects of trace metals and glutathione on renal uroporphyrinogen decarboxylase. Mol Pharmacol 1984. 26(2): 336-41.
Woods JS, et al. Urinary porphyrin profiles as a biomarker of mercury exposure: studies on dentists with occupational exposure to mercury vapor. J Toxicol Environ Health 1993. 40(2-3): 235-46.
Woods JS, et al. Quantitative measurement of porphyrins in biological tissues and evaluation of tissue porphyrins during toxicant exposures. Fundam Appl Toxicol 1993. 21(3): 291-7.
Zoroglu SS, et al. Pathophysiological role of nitric oxide and adrenomedullin in autism. Cell Biochem Funct. 2003 Mar;21(1):55-60.
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[accordion_toggle title=”Viruses and Bacteria in Autism Research”]
Bradstreet JJ, El Dahr JM, Anthony A, Kartzinel JJ, Wakefield AJ. Detection of measles virus genomic RNA in cerebrospinal fluid of children with regressive autism: a report of three cases. J Am Phys Surg. 2004:9(2):38-45.
Caruso JM et al. Persistent preceding focal neurologic deficits in children with chronic Epstein-Barr virus encephalitis. J Child Neurol. 2000 Dec;15(12):791-6.
Chess S, Fernandez P, Korn S. Behavioral consequences of congenital rubella. J Pediatr. 1978 Oct;93(4):699-703.
DeLong GR, et al. Acquired reversible autistic syndrome in acute encephalopathic illness in children. Arch Neurol. 1981 Mar;38(3):191-4.
Dyken PR. Neuroprogressive disease of post-infectious origin: a review of a resurging subacute sclerosing panencephalitis (SSPE). Ment Retard Dev Disabil Res Rev. 2001;7(3):217-25.
Ghaziuddin M et al. Autistic symptoms following herpes encephalitis. Eur Child Adolesc Psychiatry. 2002 Jun;11(3):142-6.
Gillberg IC. Autistic syndrome with onset at age 31 years: herpes encephalitis as a possible model for childhood autism. Dev Med Child Neurol. 1991 Oct;33(10):920-4.
Gillberg C. Onset at age 14 of a typical autistic syndrome. A case report of a girl with herpes simplex encephalitis. J Autism Dev Disord. 1986 Sep;16(3):369-75.
Hornig M, Weissenbock H, Horscroft N, Lipkin WI. An infection-based model of neurodevelopmental damage. Proc Natl Acad Sci USA 1999 Oct 12; 96(21):12102-7.
Hornig M, Lipkin WI. Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: Epidemiology, hypotheses, and animal models. Ment Retard Dev Disabil Res Rev 2001; 7(3):200-10.
Ivarsson SA et al. Autism as one of several disabilities in two children with congenital cytomegalovirus infection. Neuropediatrics. 1990 May;21(2):102-3.
Libbey JE, Sweeten TL, McMahon WM, Fujinami RS. Autistic disorder and viral infections. J Neurovirol. 2005 Feb;11(1):1-10.
Nicolson GL, Gan R, Nicolson NL, Haier J. Evidence for Mycoplasma ssp., Chlamydia pneunomiae, and human herpes virus-6 coinfections in the blood of patients with autistic spectrum disorders. J Neurosci Res. 2007 Apr;85(5):1143-8.
O’Leary JJ, et al. Measles virus and autism. Lancet. 2000 Aug 26;356(9231):772.
Pletnikov MV, Jones ML, Rubin SA, Moran TH, Carbone KM. Rat model of autism spectrum disorders. Genetic background effects on Borna disease virus-induced developmental brain damage. Ann N Y Acad Sci. 2001 Jun;939:318-9.
Singh VK, Jensen RL. Elevated levels of measles antibodies in children with autism. Pediatr Neurol. 2003 Apr;28(4):292-4.
Singh VK et al. Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. J Biomed Sci. 2002 Jul-Aug;9(4):359-64.
Singh VK et al. Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. Clin Immunol Immunopathol 1998 89(1):105-8.
Stubbs EG, Budden SS, Burger DR, Vandenbark AA. Transfer factor immunotherapy of an autistic child with congenital cytomega-lovirus. J Autism Dev Disord. 1980 Dec;10(4):451-8.
Stubbs EG et al. Autism and congenital cytomegalovirus. J Autism Dev Disord. 1984 Jun;14(2):183-9.
Sweeten TL, Posey DJ, McDougle CJ. Brief report: autistic disorder in three children with cytomegalovirus infection. J Autism Dev Disord. 2004 Oct;34(5):583-6.
Valsamakis A et al. Altered virulence of vaccine strains of measles virus after prolonged replication in human tissue. J Virol. 1999 73(10): 8791-7